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Hand Osteoarthritis: investigating Pain Effects in a randomised placebo-controlled feasibility study of Estrogen-containing therapy (HOPE-E)

Painful hand osteoarthritis (OA) is much more common in women around the time of the menopause, and there is some evidence that a lack of estrogen at this time may be one factor. HOPE-E is a feasibility study testing whether taking Duavive (conjugated estrogen and bazedoxifine 0.45/20mg) once a day for 6 months improves hand pain and quality of life in women with hand OA as compared to placebo.