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Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.

Original publication

DOI

10.1038/ncb2924

Type

Journal article

Journal

Nat Cell Biol

Publication Date

03/2014

Volume

16

Pages

212 - 214

Keywords

Adenocarcinoma, Animals, Colorectal Neoplasms, Female, Humans, MicroRNAs, Mitosis, Neoplastic Stem Cells, Snail Family Transcription Factors, Transcription Factors