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Numerous novel therapies are in development for rheumatoid arthritis as a consequence of tremendous progress in understanding pathogenic mechanisms and defining relevant disease cells and molecules. Anti-tumour necrosis factor alpha (TNFα) therapies have been particularly successful and set a new standard for symptom control and attenuation of structural damage to joints. Other potential therapeutic targets across a variety of disease pathways have yet to be fully validated. These include pro-inflammatory cytokines, inflammatory cells and accessory molecules. © 2004 Elsevier Ltd. All rights reserved.

Original publication

DOI

10.1016/j.ddmec.2004.10.006

Type

Journal article

Journal

Drug Discovery Today: Disease Mechanisms

Publication Date

01/01/2004

Volume

1

Pages

289 - 295