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There is a growing appreciation of the potential value of combining novel molecularly-targeted drugs with radiotherapy or chemoradiotherapy. Such approaches have the potential to improve locoregional disease control and cure rates across a diverse range of tumour types. In this report, we outline a rational framework for developing novel drug-radiation combinations. In doing so, we make recommendations regarding the core preclinical data sets that are required to serve as justification for studies in humans and describe potential clinical trial designs that may be adopted by investigators. © 2011 Cancer Research UK All Rights Reserved.

Original publication

DOI

10.1038/bjc.2011.240

Type

Journal article

Journal

British Journal of Cancer

Publication Date

23/08/2011

Volume

105

Pages

628 - 639